Preheat your oven to 375°F (190°C). Roll out the pie crust on a floured surface and transfer it to a deep-dish pan, pressing it gently into the corners. Prick the bottom with a fork and prebake for about 7–8 minutes until slightly firm.

In a large skillet over medium-high heat, cook the ground beef and Italian sausage together until browned, approximately 8–10 minutes. Drain excess grease, season with garlic powder and Italian seasoning.

Spread the ricotta cheese evenly across the bottom of the prebaked pie crust.

Sprinkle half of the shredded mozzarella cheese over the ricotta layer.

Evenly spoon the cooked meat mixture over the mozzarella layer.

Pour the pizza sauce or marinara over the meat layer and spread evenly.

Layer on the remaining mozzarella cheese on top of the sauce.

Arrange the pepperoni slices on top of the cheese layer.

Place the pie on a baking sheet and bake for 25–30 minutes until crust is golden brown and cheese is bubbly.

Remove the pie from the oven and let it rest for about 10 minutes before serving.